Home Bratislava Medical Journal 2015 Bratislava Medical Journal Vol.116, No.2, p.83-87, 2015

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2


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Bratislava Medical Journal Vol.116, No.2, p.83-87, 2015

Title: Functional and circulatory renal changes in advanced heart failure
Author: E. Demesova, E. Goncalvesova, P. Slezak, P. Pontuch


Objectives: The aim of the study was to describe the relations between heart and renal functions and to investigate whether reduced glomerular filtration rate is influenced more by reduced perfusion or venous congestion.
Methods: A prospective cohort study of 101 patients (69 men, 32 women) with chronic heart failure aged 52 (49–54) (median, 95 % confidence interval) years. We analyzed the blood samples, parameters of echocardiography and right heart catheterization.

Left ventricular ejection fraction correlated with the estimated glomerular filtration rate eGFR (r = 0.214, p = 0.036) in the whole sample of patients.

We found a correlation between cardiac output and renal perfusion pressure in the whole sample (r = 0.232, p = 0.0225) and in patients with chronic heart failure (r = 0.254, p = 0.0278).

In the whole sample the mean pulmonary artery pressure (PAP) correlated with the variables determining renal function: PAP and renal perfusion pressure (r = –0.345, p = 0.002),PAP and eGFR (r = –0.299, p = 0.009).

In the other two studied groups these correlations were not significant.
Conclusion: In the group of heart failure patients left and right ventricular functions were the main determinants for renal function. Current cardiac output or right atrial pressure as markers of renal perfusion were not associated with renal functions in advanced but stable heart failure patients with low burden of extracardiac comorbidities (Tab. 1, Fig. 4, Ref. 13).

Keywords: renal venous congestion, cardiac output, renal perfusion, cardiorenal syndrome, advanced heart failure.
Year: 2015, Volume: 116, Issue: 2 Page From: 83, Page To: 87

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