Home Bratislava Medical Journal 2015 Bratislava Medical Journal Vol.116, No.2, p.124-127, 2015

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2

 

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Bratislava Medical Journal Vol.116, No.2, p.124-127, 2015

Title: Appreciation of trimetazidine treatment in experimental sepsis rat model
Author: A. Tanoglu, L. Yamanel, V. Inal, R. Ocal, B. Comert, C. Bilgi

Abstract:

Introduction: Our aim was to determine the efficacy of trimetazidine on experimental sepsis rat model.
Material and methods: Sixty rats were randomized into three groups. In Group 1, sepsis was induced. In Group 2, sepsis was induced and as a therapeutic agent trimetazidine was given. In Group 3, rats were sham operated. Serum interleukin-1 beta (IL-1ß), tumor necrosis factor alfa (TNF-α), superoxide dismutase (SOD), glutathion peroxidase (GSH-Px) and malondialdehyde (MDA) levels were determined in all groups.
Results:

In Group 2, serum GSH-Px and SOD levels were statistically significantly higher than in Group 1 (p< 0.05) and serum MDA levels were statistically significantly lower than in group 1 (p < 0.05).

Trimetazidine also significantly decreased the levels of IL-1ß and TNF-a which are the proinflammatory cytokines (p < 0.05).


Conclusion: Trimetazidine treatment significantly improved inflammation, oxidative stress and membrane destruction in LPS-induced sepsis. As the proinflammatory cytokines are supposed to play a primary role in the pathogenesis of sepsis, we assumed that the trimetazidine treatment would give new insights into the treatment of sepsis (Tab. 1, Fig. 5, Ref. 29).



Keywords: sepsis, trimetazidine, inflammation, proinflammatory cytokines.
Year: 2015, Volume: 116, Issue: 2 Page From: 124, Page To: 127
doi:10.4149/BLL_2015_024


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