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Bratislava Medical Journal Vol.116, No.3, p.147-149, 2015 |
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Title: Soluble P-selectin glycoprotein ligand – a possible new target in ulcerative colitis | ||
Author: J. Ajdukovic, I. Salamunic, I. Hozo, B. Rosic Despalatovic, M. Simunic, D. Bonacin, Z. Puljiz, G. Trgo, Z. Sundov, A. Tonkic | ||
Abstract: ackground: The main characteristic of active inflammatory bowel disease (IBD) is the neutrophil infiltration into the intestinal lamina propria, where neutrophils usually do not reside. Selectins are cell surface glycoproteins responsible for binding the leukocytes to vascular cells and their extravasation into the surrounding tissue. They show high affinity to P-selectin glycoprotein ligand-1 (PSGL-1) receptors. PSGL-1 is expressed on the surface of all leukocytes and they mediate the rolling of neutrophils on P-selectin. Soluble PSGL-1 acts competitively with cellular PSGL in many physiological and pathological processes. The mean (± standard deviation) serum concentrations of sPSGL-1 in patients with UC and controls were 349.97±75.40 U/mL and 284.39±52.40 U/mL, respectively (p=0.003).
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Keywords: ulcerative colitis, P-selectin glycoprotein ligand-1. | ||
Year: 2015, Volume: 116, Issue: 3 | Page From: 147, Page To: 149 | |
doi:10.4149/BLL_2015_029 |
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