Home Bratislava Medical Journal 2015 Bratislava Medical Journal Vol.116, No.3, p.157-161, 2015

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2

 

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Bratislava Medical Journal Vol.116, No.3, p.157-161, 2015

Title: Methylene blue as an antioxidant agent in experimentally-induced injury in rat liver
Author: B. Bozkurt, E. G. Dumlu, M. Tokac, A. B. Ozkardes, M. Ergin, S. Orhun, M. Kilic

Abstract: Background: We aimed to test the methylene blue (MB) as a dye and also to test its antioxidant activities in devascularization-induced liver injury.
Methods: Twenty rats weighing 240–280 g were randomly divided into two groups, each containing 10 rats. High-grade liver injury was induced by using a pair of long pliers with blades. MB was injected into portal vein of the rats with no hepatic injury (Group 1; control group) and those with injured livers (Group 2; injury group). Liver and hepatic function tests, paraoxonase, stimulated paraoxonase, arylesterase activity, total antioxidant, and oxidant status were evaluated before and 24 h after MB injection.
Results: MB did not stain the non-perfused area. Total antioxidant status decreased significantly in Group 2 at hour 24 compared to Group 1. In Group 2, total antioxidant status was lower at hour 24 compared to hour 0. Total oxidant status in Group 2 at hour 0 increased significantly compared to Group 1. Total oxidant status in Group 2 at hour 24 was lower compared to that at hour 0. Lipid peroxidation parameters did not alter due to devascularization.
Conclusion: MB is useful in defining the devascularization area. Moreover, it showed to have a beneficial effect on oxidant status (Tab. 3, Fig. 3, Ref. 25).

Keywords: devascularization, liver, injury, methylene blue, rat.
Year: 2015, Volume: 116, Issue: 3 Page From: 157, Page To: 161
doi:10.4149/BLL_2015_032


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