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Bratislava Medical Journal Vol.116, No.3, p.167-172, 2015 |
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Title: Use of infliximab in treatment of acute pancreatitis | ||
Author: S. Ozcevik Tekin, S. Teksoz, D. Terzioglu, A. E. Arikan, H. Ozcevik, E. Uslu | ||
Abstract: Objective:The aim of this study was to investigating the effects of infliximab in severe necrotizing pancreatitis. In group I serum sialic acid, malondialdehyde, carbonyl content and amylase activity were significantly lower than in group II (p<0.01). There were no significant differences for serum TAA between group I and II (p>0.05). Tissue sialic acid and malondialdehyde in group I were significantly lower than in group II (p<0.01). But tissue TAA in group I was significantly higher than in group II (p<0.01). Carbonyl content of group I was not significantly different from group II (p>0.05). Histopathologically, pancreatic sections of group II demonstrated extensive acinar and fat necrosis, hemorrhage, and inflammation. In group I Infliximab improved histopathological changes (p0.05).
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Keywords: acute necrotizing pancreatitis, infliximab, TNF-alpha; taurocholate,malondialdehyde,amylase,antioxidants,sialic acid | ||
Year: 2015, Volume: 116, Issue: 3 | Page From: 167, Page To: 172 | |
doi:10.4149/BLL_2015_034 |
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