Home Bratislava Medical Journal 2015 Bratislava Medical Journal Vol.116, No.4, p.241-247, 2015

Journal info


Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564


Aims and Scope
Editorial Info
Submission Guidelines

Select Journal

Webshop Cart

Your Cart is currently empty.

Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

Bratislava Medical Journal Vol.116, No.4, p.241-247, 2015

Title: The histopathological effects of levosimendan on liver injury induced by myocardial ischemia and reperfusion
Author: G. L. Oktar, N. Demir Amac, C. Elmas, M. Arslan, G. Goktas, E. Iriz, D. Erer, M. H. Zor, T. Tatar


Background: The aim of this study was to evaluate the histological and immunohistochemical effects of levosimendan on liver injury induced by myocardial ischemia and reperfusion (I/R) in a rat model.

Methods: Twenty-four male Wistar Albino rats were randomly divided into the four groups: Group C (Control, n = 6), Group I/R (n = 6), Group BI (I/R group treated with levosimendan before ischemia, n = 6), and Group AI (I/R group treated with levosimendan after ischemia, n = 6).

Myocardial I/R was induced by ligation of the left anterior descending coronary artery for 30 min followed by two hours of reperfusion in I/R and I/R+Levosimendan groups. At the end of the study, liver tissue samples were obtained for histopathological and immunohistochemical examination.
Results: Masson Trichrome staining revealed significant hepatocyte degeneration and necrosis most marked in portal acinus Zone 3, especially around the central veins in Group I/R. Histopathological changes in Group AI were more similar to the changes in Group I/R. Milder hepatocellular degeneration was found in Group BI, when compared to groups I/R and AI.

Immunohistochemical score was found to be significantly higher in Group I/R compared to groups C, BI and AI (p < 0.0001).

The scores in groups BI and AI were found to be similar (p = 0.068).

Conclusion: Levosimendan ameliorates liver injury induced by myocardial IR, especially when administered before induction of ischemia (Fig. 9, Ref. 37).

Keywords: levosimendan, myocardial ischemia reperfusion, remote organ, liver injury, i-NOS, rat.
Year: 2015, Volume: 116, Issue: 4 Page From: 241, Page To: 247

download file

© AEPress s.r.o
Copyright notice: For any permission to reproduce, archive or otherwise use the documents in the ELiS, please contact AEP.