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Bratislava Medical Journal Vol.116, No.4, p.241-247, 2015 |
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Title: The histopathological effects of levosimendan on liver injury induced by myocardial ischemia and reperfusion | ||
Author: G. L. Oktar, N. Demir Amac, C. Elmas, M. Arslan, G. Goktas, E. Iriz, D. Erer, M. H. Zor, T. Tatar | ||
Abstract: Background: The aim of this study was to evaluate the histological and immunohistochemical effects of levosimendan on liver injury induced by myocardial ischemia and reperfusion (I/R) in a rat model.
Myocardial I/R was induced by ligation of the left anterior descending coronary artery for 30 min followed by two hours of reperfusion in I/R and I/R+Levosimendan groups. At the end of the study, liver tissue samples were obtained for histopathological and immunohistochemical examination. Immunohistochemical score was found to be significantly higher in Group I/R compared to groups C, BI and AI (p < 0.0001). The scores in groups BI and AI were found to be similar (p = 0.068). |
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Keywords: levosimendan, myocardial ischemia reperfusion, remote organ, liver injury, i-NOS, rat. | ||
Year: 2015, Volume: 116, Issue: 4 | Page From: 241, Page To: 247 | |
doi:10.4149/BLL_2015_047 |
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