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Bratislava Medical Journal Vol.116, No.4, p.248-251, 2015 |
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Title: Gamma-secretase inhibitor does not modulate angiogenesis in colon adenocarcinoma in obese mice | ||
Author: M. Khazaei, E. Kalantari, H. Saeidi, N. ShabaniKia, Z. Tahergorabi, B. Rashidi, N. Dana, S. H. Javanmard | ||
Abstract: Background: Notch is a signaling molecule which plays a role in angiogenesis and γ-secretase is required for processing of Notch. In this study, we investigated the effect of γ-secretase inhibitor (DAPT) on tumor angiogenesis in diet-induced obese mice. When the tumor size reached approximately 350 ± 50 mm3, half of the obese animals received DAPT (10mg/kg/day) subcutaneously. Blood samples were taken after 14 days and the tumors harvested for immunohistochemical staining and capillary density were reported as CD31 positive cells/mm2. Administration of DAPT in obese mice significantly reduced serum VEGFR-1 and leptin concentrations and increased serum NO level (p < 0.05). Capillary density in the tumors of obese animals was not different compare to control groups. DAPT administration could not alter capillary density in the tumors. |
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Keywords: γ-secretase, obese, angiogenesis, adenocarcinoma. | ||
Year: 2015, Volume: 116, Issue: 4 | Page From: 248, Page To: 251 | |
doi:10.4149/BLL_2015_048 |
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