Home Bratislava Medical Journal 2015 Bratislava Medical Journal Vol.116, No.4, p.259-263, 2015

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564


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Bratislava Medical Journal Vol.116, No.4, p.259-263, 2015

Title: Topiramate has protective effect on renal injury
Author: M. C. Cure, E. Cure, L. Tumkaya, Y. Kalkan, I. Aydin, A. Kirbas, H. Efe, I. Sehitoglu, S. Yuce


Background: Topiramate (TPM) decreases tumor necrosis factor-alpha (TNF-α) and oxidative stress. We investigated protective effects of TPM on cell damage in kidney tissue during ischemia-reperfusion (I/R) damage.
Methods: A total of 30 male Wistar albino rats were divided into three groups: control, I/R, and I/R plus TPM (I/R+TPM). Laparotomy without I/R injury was performed in control group. After laparotomy, cross ligation of infrarenal abdominal aorta was applied for two hours in I/R groups which was followed by two hours of reperfusion. TPM (100 mg/kg/day) was orally administrated to animals in the I/R+TPM group for seven consecutive days before I/R.

The I/R group’s TNF-α and interleukin-1 beta (IL-1β) levels were significantly higher (1184.2 ± 129.1 pg/mg protein; 413.1 ± 28.8 pg/mg protein, respectively) than those of the control (907.8 ± 113.0 pg/mg protein, p = 0.002; 374.7 ± 23.7 pg/mg protein, p = 0.010, respectively) and I/R+TPM groups (999.5 ± 115.2 pg/mg protein, p < 0.001; 377.9 ± 30.9 pg/mg protein, p = 0.007, respectively).

Conclusion: TPM may partially prevent renal damage in rats. The opening of new horizons of this kind of knowledge will help understand the complex challenge in the prevention of renal I/R damage (Tab. 1, Fig. 3, Ref. 42).

Keywords: topiramate, ischemia reperfusion, kidney, carbonic anhydrase II.
Year: 2015, Volume: 116, Issue: 4 Page From: 259, Page To: 263

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