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Bratislava Medical Journal Vol.116, No.4, p.259-263, 2015 |
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Title: Topiramate has protective effect on renal injury | ||
Author: M. C. Cure, E. Cure, L. Tumkaya, Y. Kalkan, I. Aydin, A. Kirbas, H. Efe, I. Sehitoglu, S. Yuce | ||
Abstract: Background: Topiramate (TPM) decreases tumor necrosis factor-alpha (TNF-α) and oxidative stress. We investigated protective effects of TPM on cell damage in kidney tissue during ischemia-reperfusion (I/R) damage. The I/R group’s TNF-α and interleukin-1 beta (IL-1β) levels were significantly higher (1184.2 ± 129.1 pg/mg protein; 413.1 ± 28.8 pg/mg protein, respectively) than those of the control (907.8 ± 113.0 pg/mg protein, p = 0.002; 374.7 ± 23.7 pg/mg protein, p = 0.010, respectively) and I/R+TPM groups (999.5 ± 115.2 pg/mg protein, p < 0.001; 377.9 ± 30.9 pg/mg protein, p = 0.007, respectively). |
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Keywords: topiramate, ischemia reperfusion, kidney, carbonic anhydrase II. | ||
Year: 2015, Volume: 116, Issue: 4 | Page From: 259, Page To: 263 | |
doi:10.4149/BLL_2015_050 |
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