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Bratislava Medical Journal Vol.116, No.4, p.270-275, 2015 |
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Title: Candesartan mediates microcirculation in acute necrotizing pancreatitis | ||
Author: H. Bostanci, T. T. Sahin, K. Dikmen, A. U. Dikmen, O. Yuksel, O. Gulbahar, A. Poyraz, E. Tekin | ||
Abstract: Aim: In the present study we aimed to determine the effect of an AT-II antagonist candesartan on pancreatic microcirculation in an experimental model of acute necrotizing pancreatitis. Pancreatic microcirculation was higher in the candesartan treated groups (p < 0.05). Myeloperoxidase, IL-6 and tumour necrosis factor alpha was found to be lower in the candesartan treated groups (p < 0.05). The pancreatic edema and inflammation were found to be reduced in the candesartan treated groups (p < 0.05). Endothelial apoptosis was found to be reduced by cadesartan treatment but it did not reach statistical significance (p > 0.05). Tissue matrix metalloproteinase -9 levels were found to be reduced with candesartan treatment (p < 0.05). |
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Keywords: acute necrotizing pancreatitis, microvascular circulation, candesartan, matrix metalloproteinase. | ||
Year: 2015, Volume: 116, Issue: 4 | Page From: 270, Page To: 275 | |
doi:10.4149/BLL_2015_052 |
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