Home Bratislava Medical Journal 2015 Bratislava Medical Journal Vol.116, No.4, p.276-279, 2015

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2

 

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Bratislava Medical Journal Vol.116, No.4, p.276-279, 2015

Title: Chronic morphine, naltrexone and pentoxifylline effect on hypophyso-gonadal hormones of male rats
Author: M. Moradi, M. Mahmoodi, A. Raoofi, A. Ghanbari

Abstract: Background: Knowledge about harmful effects of morphine on hormone secretion seems to be necessary. The aim of the present study was to evaluate the effect of pentoxifylline on side effects derived by morphine on hypophyso-gonadal hormones of male rats.
Methods: 32 male rats were divided into the 4 groups of OSS: control (received 40 g Sucrose/l drinking water and intraperitoneal injection of 1 l/kg normal saline), OMS: morphine group (received 0.4 mg/l + 40 g Sucrose/l in drinking water and intraperitoneal injection of 1 l/kg normal saline), NMS: morphine+naltrexone group (received 0.4 mg/l + 40 g Sucrose/l in drinking water and IP injection dose of 10 mg/kg/ml/day Naltrexone) and PMS: morphine + pentoxifylline group (received 0.4 mg/dl + 40 g Sucrose/l in drinking water and IP injection dose of 12 mg/kg/ml/day Pentoxifylline) for 56 days, respectively.
Results: Serum levels of testosterone, LH, FSH hormones were measured. Pentoxifylline increased serum levels of testosterone, LH, FSH hormones compared to control, morphine and morphine-naltrexone groups.
Conclusion: Pentoxifylline has a significant efficacy for increasing serum levels of sexual hormones. Considering that Pentoxifylline is safe and cheap, with easy application, we suggest for the usage of this drug for improving semen parameter’s quality before performing ART for the treatment of morphine addicts (Fig. 1, Ref. 31).

Keywords: morphine, naltrexane, pentoxifylline, rat.
Year: 2015, Volume: 116, Issue: 4 Page From: 276, Page To: 279
doi:10.4149/BLL_2015_053


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