Home HOME Neoplasma 2015 Neoplasma Vol.62, No.3, p.372-383, 2015

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.62, No.3, p.372-383, 2015

Title: Arteriogenic expansion of extratumoral macrovessels – impact of vascular ageing

Abstract: The critical role of the vasculature in cancer progression is predominantly studied at the capillary level, and often equated with angiogenesis. However, the mechanisms that ensure the supply of increasing blood volume to the expanding tumor microcirculation remain presently unclear. Here we used established mouse tumor models to document the enlargement (arteriogenesis), of macroscopic feeding vessels at considerable distances upstream from the malignant lesion, but not contralaterally. These changes are not affected by the procoagulant host tissue factor (TF), but are modulated by vascular ageing and atherosclerosis in ApoE-/- mice. Moreover, arteriogenic growth involves infiltration of bone marrow derived (YFP-labeled) cells and changes the gene expression profiles in the vessel wall. Thus, our observations suggest that in addition to local angiogenesis tumors influence distant remodeling of regional macroscopic blood vessels in a manner that is modulated by certain vascular comorbidities.

Keywords: cancer, angiogenesis, arteriogenesis, ageing, atherosclerosis
Published online: 01-Apr-2015
Year: 2015, Volume: 62, Issue: 3 Page From: 372, Page To: 383

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