Home HOME Neoplasma 2015 Neoplasma Vol.62, No.3, p.391-397, 2015

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.62, No.3, p.391-397, 2015

Title: 17-AAG enhances the cytotoxicity of flavopiridol in mantle cell lymphoma via autophagy suppression
Author: Y. XIAO, J. GUAN

Abstract: Flavopiridol, a cyclin-dependent kinase inhibitor (CDKI), shows promising anti-tumor activity in hematologic malignancies. However, Flavopiridol-induced protective autophagy may lead to drug resistance. Here we found that Hsp90 inhibitor 17-AAG can sensitize mantle cell lymphoma (MCL) cells to flavopiridol by suppressing flavopiridol-triggered protective autophagy. The suppressing effect of 17-AAG on autophgy was mediated by Beclin1 degradation and ERK inactivation. Furthermore, 17-AAG enhanced flavopiridol-induced apoptosis and growth suppression in MCL cells. Our study may provide some insights into CDKI -targeted chemotherapies.

Keywords: flavopiridol, 17-AAG, MCL, autophagy
Published online: 01-Apr-2015
Year: 2015, Volume: 62, Issue: 3 Page From: 391, Page To: 397

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