Home General Physiology and Biophysics 2015 General Physiology and Biophysics Vol.34, No.2, p.201–207, 2015

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Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
Published in English,
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General Physiology and Biophysics Vol.34, No.2, p.201–207, 2015

Title: Cytotoxic effect of extract from Dunaliella salina against SH-SY5Y neuroblastoma cells
Author: Belkis Atasever-Arslan, Kaan Yilancioglu, Maide G. Bekaroglu, Emre Taskin, Eyup Altinozand Selim Cetiner
Abstract: Cytotoxic effects of essential oils extracted from Dunaliella salina on SH-SY5Y human neuroblastoma cells were investigated in this study. GC-MS analysis was used for determination of the composition of essential oils found in Dunaliella salina extract. All experimented concentrations of Dunaliella salina extract on SH-SY5Y human neuroblastoma cells were significantly more cytotoxic than the tested concentrations of the extract on ECV304 human endothelial cells used as a control. Fifthy compounds were detected in GC-MS analysis of the extract, and five major compounds were predominantly found as follows: octadecanoic acid, methyl ester (27.43%); hexadecanoic acid, methyl ester (Cas) methyl palmitate (24.82%); 9,12,15-octadecatrienoic acid, ethyl ester, (Z,Z,Z)- (7.39%); octadecanoic acid (5.03%), pentadecanoic acid (3.60%). The cytotoxic activity of Dunaliella salina extract on SH-SY5Y human neuroblastoma cells might be due to high concentrations of octadecanoic acid and hexadecanoic acid. Furthermore, results indicate that the extract demonstrates some proliferative effect on ECV304 cells in a dose-dependent manner between 0.25 and 5 μg/ml. These results suggest that Dunaliella salina may have anticancer potential against human neuroblastoma cells.
Keywords: Algae — Cytotoxicity — Dunaliella salina — Essential oil — SH-SY5Y human neuroblastoma cells
Year: 2015, Volume: 34, Issue: 2 Page From: 201, Page To: 207
doi:10.4149/gpb_2014034


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