Home Bratislava Medical Journal 2015 Bratislava Medical Journal Vol.116, No.5, p.289-295, 2015

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564


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Bratislava Medical Journal Vol.116, No.5, p.289-295, 2015

Title: Avascular necrosis of bone in childhood cancer patients: a possible role of genetic susceptibility
Author: L. Geczova, A. Soltysova, J. Gecz, S. Sufliarska, J. Horakova, B. Mladosievicova

Abstract: With the increasing number of paediatric cancer patients and with their prolonged survival, the evidence of a number of serious complications induced by anticancer therapy is rising. Osteonecrosis (ON) of bone is one of these treatment-related effects with a multifactorial pathogenesis. In the past few years, several polymorphisms of candidate genes with possible role in development of this disorder were studied.
We summarized potential risk factors leading to increased susceptibility to osteonecrosis of bone development in cancer patients during childhood and to present current knowledge in the field of genetic aspects of this condition (Ref. 86).

Keywords: osteonecrosis, avascular necrosis, anticancer treatment, corticosteroids, transplantation, genetic determinants.
Year: 2015, Volume: 116, Issue: 5 Page From: 289, Page To: 295

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