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Bratislava Medical Journal Vol.116, No.5, p.326-329, 2015 |
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Title: The effect of nesfatin-1 on heart L-type Ca2+ channel α1c subunit in rats subjected to chronic restraint stress | ||
Author: C. Ayada, G. Turgut, S. Turgut | ||
Abstract: Background: Elevated L-type Ca2+ channel expression level increases Ca2+ influx. This can cause hypertrophy and pathological remodeling of the heart especially under stress conditions. Nesfatin-1 can activate hypothalamic L, P and Q type Ca2+ channels and increase insulin secretion in pancreatic islet beta cells via activation of L-type Ca2+ channels. On the other hand, the effect of nesfatin-1 on cardiac L-type Ca2+ channels has not been studied yet.
Rats in groups subjected to restraint stress were placed in a specially built size-manipulable cabin for 2 h/day (between 10:00 and 12:00 a.m.) for 10 consecutive days without allowing water and food intake. Nesfatin-1 segment (0.25 nmol/g bw intraperitoneally) was applied during the 10 consecutive days. Western blot analyses were performed to determine the expression level of L-type Ca2+ channel α1c subunit protein in rat cardiac extracts. Results: Cardiac L-type Ca2+ channel α1c subunit protein expression levels were increased significantly after chronic peripheral nesfatin-1 application in rats subjected to restraint stress (p = 0.032). |
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Keywords: nesfatin-1, chronic restraint stress, cardiac failure, L-type Ca2+ channel α1c subunit, Western blot. | ||
Year: 2015, Volume: 116, Issue: 5 | Page From: 326, Page To: 329 | |
doi:10.4149/BLL_2015_061 |
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