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Neoplasma Vol.62, No.4, p.610-617, 2015 |
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Title: Clinicopathologic, surgical characteristics and survival outcomes of rectal gastrointestinal stromal tumors | ||
Author: C. SHEN, H. CHEN, R. YIN, Y. YIN, J. CHEN, L. HAN, B. ZHANG, Z. CHEN, J. CHEN | ||
Abstract: Rectal gastrointestinal stromal tumors (GISTs) are rare, and limited information is available concerning their management and long-term outcomes. We retrospectively evaluated the clinicopathological characteristics, surgical management, and long-term outcomes of rectal GISTs from a single institution. Patients presented with rectal bleeding (n = 13; 28.9%) and altered bowel habits (n = 11; 24.4%). The cohort study of 45 patients included 4 very low-risk, 10 low-risk, 1 intermediate-risk, and 30 high-risk patients. A total of 21, 13, and 11 patients underwent local resection (Group 1), abdominoperineal resection (Group 2), and super-low or low anterior resection (Group 3), respectively. Group 1 had a smaller tumor sizes and shorter distances from the anal verge compared with the other groups (P < 0.05). The one-, three-, and five-year DFS rates for the entire cohort study were 90.4%, 69.3%, and 57.0%, respectively. High National Institutes of Health (NIH) risk categories (HR = 1.62) were associated with low DFS rates (P = 0.035). The DFS was significantly improved by imatinib mesylate (IM) adjuvant therapy in the high-risk subgroup (P = 0.001). |
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Keywords: gastrointestinal stromal tumors, rectum, clinicopathologic | ||
Published online: 20-May-2015 | ||
Year: 2015, Volume: 62, Issue: 4 | Page From: 610, Page To: 617 | |
doi:10.4149/neo_2015_073 |
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