Home Bratislava Medical Journal 2015 Bratislava Medical Journal Vol.116, No.6, p.363-367, 2015

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2


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Bratislava Medical Journal Vol.116, No.6, p.363-367, 2015

Title: The effects of Nano titanium dioxide (TiO2NPs) on lung tissue
Author: F. Mohammadi, L. Sadeghi, A. Mohammadi, F. Tanwir, V. Yousefi Babadi, M. Izadnejad

Abstract: OBJECTIVES: The application of nanoparticles is widely spread in all aspects of modern life because of their unique features such as small size and high surface area. High surface area can be very reactive and produce reactive oxygen species (ROS). These nanoparticles can damage human and animal cells by increasing oxidative stress mechanism. Titanium dioxide nanoparticles (TiO2NPs) are among the top five nanoparticles used in consumer products, paints, and pharmaceutical preparations.TiO2 NPs have various capabilities such as robust oxidation, biocompatibility and photocatalytic properties. They are frequently used in a wide range of sciences, including pharmaceuticals, cosmetics, medicine and engineering. The ever increasing industrial and consumer applications of TiO2NPs raise concern over the possible risk association with their environmental exposure.
METHODS: This study investigates the effects of TiO2NP on lung tissue by intraperitoneal injection to rats at different doses (15, 30, 60 and 70 mg/kg).
RESULTS: Our results showed that intraperitoneal injection of TiO2NP creates capillary congestion and hemorrhage in alveolar wall, granulomas in lung parenchyma, and hemosiderin depositions in blood vessels adjacent to bronchioles without any inflammation. The pulmonary side effects could be due to the production of ROS post TiO2NP exposure (Tab. 1, Fig. 5, Ref. 27).

Keywords: titanium dioxide nanoparticle, lung tissue, reactive oxygen species, alveolar wall, inflammation.
Published online: 09-Jun-2015
Year: 2015, Volume: 116, Issue: 6 Page From: 363, Page To: 367

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