Home Bratislava Medical Journal 2015 Bratislava Medical Journal Vol.116, No.6, p.389-393, 2015

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Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

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Bratislava Medical Journal Vol.116, No.6, p.389-393, 2015

Title: Risk factors for severe outcome of cases with pandemic influenza A(H1N1)pdm09
Author: L. Hlavinkova, Z. Kristufkova, J. Mikas


OBJECTIVES: The aim of this study is to describe demographic, clinical and epidemiological characteristics of cases with laboratory-confirmed pandemic influenza virus A(H1N1)pdm09 reported in Slovakia from May 28, 2009 to December 30, 2009 and analyse the association between risk factors and severe outcome of these cases.
BACKGROUND: In the spring of 2009, an outbreak of a pandemic influenza virus A(H1N1)pdm09, emerged in Mexico and spread globally. Until December 2009, 1,014 cases were notified in Slovakia.
METHODS: The data were collected within national influenza surveillance system. Odds ratios (95% CI) were calculated.

Associations were found to be significantly associated with the worse outcome (p < 0.05) in the univariate analysis and were adjusted for possible effects of age and sex by using a logistic regression model.

RESULTS: Out of the total number of 1,014 cases, 131 (12.9 %) cases were hospitalized, and 43 (4.2 %) of those were admitted to intensive care units.

During the reporting period, 38 deaths were reported, representing a case fatality rate of 3.75 %.

The median age of severe cases (35 years, IQR = 29 y) was significantly higher than the median age of mild cases (24 years, IQR = 19 y; p < 0.001).

By using a logistic regression, we found out that chronic obstructive pulmonary disease (COPD) (aOR = 9.2; 95%CI: 1.42–59.98), cardiovascular diseases (aOR = 14.97; 95%CI: 5.49–40.79), malignity (aOR = 7.6; 95%CI: 1.95–29.37) and gravidity (aOR = 55.21; 95% CI: 14.40–211.58) were significantly associated with severe outcomes of the cases.

CONCLUSION: The fact, that 35% of severely ill patients did not report any risk factor suggests the importance of vaccination as a prevention of influenza (Tab. 2, Fig. 1, Ref. 18).

Keywords: pandemic influenza A(H1N1)pdm09, risk factor, severe outcome of the disease.
Published online: 09-Jun-2015
Year: 2015, Volume: 116, Issue: 6 Page From: 389, Page To: 393

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