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Bratislava Medical Journal Vol.116, No.6, p.389-393, 2015 |
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Title: Risk factors for severe outcome of cases with pandemic influenza A(H1N1)pdm09 | ||
Author: L. Hlavinkova, Z. Kristufkova, J. Mikas | ||
Abstract: OBJECTIVES: The aim of this study is to describe demographic, clinical and epidemiological characteristics of cases with laboratory-confirmed pandemic influenza virus A(H1N1)pdm09 reported in Slovakia from May 28, 2009 to December 30, 2009 and analyse the association between risk factors and severe outcome of these cases. Associations were found to be significantly associated with the worse outcome (p < 0.05) in the univariate analysis and were adjusted for possible effects of age and sex by using a logistic regression model.
During the reporting period, 38 deaths were reported, representing a case fatality rate of 3.75 %. The median age of severe cases (35 years, IQR = 29 y) was significantly higher than the median age of mild cases (24 years, IQR = 19 y; p < 0.001). By using a logistic regression, we found out that chronic obstructive pulmonary disease (COPD) (aOR = 9.2; 95%CI: 1.42–59.98), cardiovascular diseases (aOR = 14.97; 95%CI: 5.49–40.79), malignity (aOR = 7.6; 95%CI: 1.95–29.37) and gravidity (aOR = 55.21; 95% CI: 14.40–211.58) were significantly associated with severe outcomes of the cases.
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Keywords: pandemic influenza A(H1N1)pdm09, risk factor, severe outcome of the disease. | ||
Published online: 09-Jun-2015 | ||
Year: 2015, Volume: 116, Issue: 6 | Page From: 389, Page To: 393 | |
doi:10.4149/BLL_2015_074 |
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