Journal info
|
||
Select Journal
Journals
Bratislava Medical Journal Endocrine Regulations General Physiology and Biophysics Neoplasma Acta Virologica Current articles 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
Acta Virologica Vol.59, No.2, p.103-116, 2015 |
||
Title: Unravelling viral camouflage: approaches to the study and characterization of conformational epitopes | ||
Author: T. AUGUSTIN, O. CEHLAR, R. SKRABANA, P. MAJEROVA, J. HANES | ||
Abstract: Antibodies are broadly used in clinical and basic research. Many of monoclonal antibodies are successfully adopted for therapeutic and diagnostic targeting of viral pathogens. Efficacy of antiviral neutralizing or protective antibodies depends on their ability to recognize epitopes interfering with viral infection. However, viruses are able to incessantly change their antigenic determinants to escape surveillance of humoral immune system and therefore the successful antiviral therapies require continuous development. Characterization of interactions of antibodies with prevalently conformational viral epitopes is important for understanding antibody mode of action and can help to identify conserved regions that may be exploited in designing new vaccines and virus neutralizing antibodies. In this article, we are reviewing techniques in use for characterization of conformational epitopes of monoclonal antibodies with focus on viruses. |
||
Keywords: monoclonal antibody; conformational epitope; X-ray crystallography; NMR; display technologies; mass spectrometry | ||
Published online: 22-Jun-2015 | ||
Year: 2015, Volume: 59, Issue: 2 | Page From: 103, Page To: 116 | |
doi:10.4149/av_2015_02_103 |
||
|
download file |
|