Home General Physiology and Biophysics 2015 General Physiology and Biophysics Vol.34, No.3, p.301–310, 2015

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Founded: 1982
ISSN  1338-4325 (online)

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General Physiology and Biophysics Vol.34, No.3, p.301–310, 2015

Title: Biphasic response of cardiodynamic adaptations to swimming exercise in rats
Author: Jelica T. Stojanovic Tosic , Vladimir Lj. Jakovljevic, Vladimir V. Zivkovic, Ivan M. Srejovic, Zoran J. Valdevit, Dragan S. Radovanovic, Dragan M. Djuric, Zlatko K. Ahmetovic, Dusan B. Peric, Marija B. Cankovic, Maja S. Jovanovic, Dusica Z. Djordjevic


The aim of research was to assess exercise-induced changes in mechanics of hearts isolated from rats, as well as time-course of those changes.

Wistar rats (n = 42) were divided into control, moderately trained (swimming 1 hour, 5 days a week for 9 or 12 weeks) and strenuously trained (swimming 2, 3 and 4 times a day for an hour in weeks 10, 11 and 12, respectively) groups.


After sacrificing, hearts (weight: 1480.82 ± 145.38 mg) were isolated and perfused on a Langendorff apparatus. Coronary perfusion pressure (CPP) was gradually increased (from 40 to 120 cmH2O) in order to establish coronary autoregulation.

Parameters of cardiac contractility were recorded: maximum and minimum rate of change of pressure in the left ventricle (dp/dt max and dp/dt min), systolic and diastolic left ventricular pressure (SLVP and DLVP), heart rate (HR) and coronary flow (CF). Nine weeks of moderate exercise induced slight depression of coronary function (decrease of dp/dt max, dp/dt min, SLVP and DLVP), while 3 additional weeks of moderate training improved hearts function, but not to the extent that the strenuous training program did. The results of our study add evidence about beneficial effects of regular moderate exercise on heart, and furthermore, show that exercising frequently, if the intensity stays within moderate range, may not have detrimental effects on cardiodynamics.

Keywords: Rats — Swimming — Isolated rat heart — Cardiodynamics — Coronary flow
Published online: 22-Jun-2015
Year: 2015, Volume: 34, Issue: 3 Page From: 301, Page To: 310

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