Home Neoplasma 2015 Neoplasma Vol.62, No.5, p.765-769, 2015

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ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.62, No.5, p.765-769, 2015

Title: Association of BCSC-1 with human esophageal squamous cell carcinoma
Author: C. L. ZHAO, W. J. YU, Z. Q. GAO, W. T. LI, W. GAO, W. W. YANG, W. G. FENG, J. Y. JU


Breast cancer suppressor candidate-1 (BCSC-1) is a newly identified candidate tumor suppressor gene. BCSC-1 shows decreased levels in a variety of cancer types. In this study, we investigated the association between BCSC-1 and human esophageal squamous cell carcinoma (ESCC). BCSC-1 expression was detected in ESCC and normal tissues adjacent to tumor tissues by Western blot analysis and real-time PCR  as well as immunohistochemistry of paraffin sections. The relationships between BCSC-1 expression and various clinicopathological characteristics were analyzed. Western blot analysis and real-time PCR showed that levels of BCSC-1 protein and mRNA expression in ESCC significantly decreased compared with those in adjacent normal tissues.  Immunohistochemistry exhibited marked reduction of BCSC-1 in 38 of 105 ESCC specimens. Moreover, downregulation of BCSC-1 was associated with the grade of tumor cellular differentiation (P<0.05).

These findings indicate that BCSC-1 downregulation in ESCC is associated with carcinogenesis and may play important roles during the process of ESCC cancer development.

Keywords: BCSC-1, ESCC, immunohistochemistry
Published online: 03-Aug-2015
Year: 2015, Volume: 62, Issue: 5 Page From: 765, Page To: 769

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