Home Bratislava Medical Journal 2015 Bratislava Medical Journal Vol.116, No.8, p.494–498, 2015

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564


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Bratislava Medical Journal Vol.116, No.8, p.494–498, 2015

Title: Rosuvastatin-induced responses in calf cardiac vein
Author: K. E. Nurullahoglu-Atalik, M. Oz, A. Shafiyi

Abstract: OBJECTIVE: The effects of Rho-kinase inhibitors on vasodilatation induced by 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor rosuvastatin (10–9–10–4M) on 5-HT-precontracted calf cardiac vein and the role of endothelium in these effects were analyzed.
MATERIAL AND METHODS: Cardiac vein ring preparations were suspended in organ baths containing 25 ml of Krebs–Henseleit solution, maintained at 37 °C and continuously gassed with 95 % O2–5 % CO2. At the end of the resting period, the cardiac vein preparations were contracted with 10–6 M 5-HT. After the contraction had reached a steady state, rosuvastatin was added to the organ bath cumulatively (10–9–10–4M).
RESULTS: Rosuvastatin relaxed the cardiac vein rings in general while the degree of relaxation was greater in those with endothelium and lower in those without it. HA1077 [1-(5-isoquinolinesulfonyl)-homopiperazine] (Fasudil, 10–6 M) and Y-27632 [(+)-(R)-trans-4-(1-aminoethyl)-N-(4-pyridyl) cyclohexane carboxamide dihydrochloride] (10–6 M) incubation increased the rosuvastatin-induced relaxation only in the presence of endothelium.
CONCLUSIONS: The results demonstrate for the first time that in calf cardiac vein, rosuvastatin induced endothelium-dependent relaxations while Rho-kinase inhibition increased these relaxations in the presence of endothelium layer (Fig. 3, Ref. 44).

Keywords: calf cardiac vein, endothelium-dependent relaxation, Rho-kinase, rosuvastatin
Published online: 24-Aug-2015
Year: 2015, Volume: 116, Issue: 8 Page From: 494, Page To: 498

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