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Bratislava Medical Journal 2015 Bratislava Medical Journal Vol.116, No.8, p.494–498, 2015
Bratislava Medical Journal 2015 Bratislava Medical Journal Vol.116, No.8, p.494–498, 2015
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Bratislava Medical Journal Vol.116, No.8, p.494–498, 2015 |
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| Title: Rosuvastatin-induced responses in calf cardiac vein | ||
| Author: K. E. Nurullahoglu-Atalik, M. Oz, A. Shafiyi | ||
| Abstract: OBJECTIVE: The effects of Rho-kinase inhibitors on vasodilatation induced by 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor rosuvastatin (10–9–10–4M) on 5-HT-precontracted calf cardiac vein and the role of endothelium in these effects were analyzed. MATERIAL AND METHODS: Cardiac vein ring preparations were suspended in organ baths containing 25 ml of Krebs–Henseleit solution, maintained at 37 °C and continuously gassed with 95 % O2–5 % CO2. At the end of the resting period, the cardiac vein preparations were contracted with 10–6 M 5-HT. After the contraction had reached a steady state, rosuvastatin was added to the organ bath cumulatively (10–9–10–4M). RESULTS: Rosuvastatin relaxed the cardiac vein rings in general while the degree of relaxation was greater in those with endothelium and lower in those without it. HA1077 [1-(5-isoquinolinesulfonyl)-homopiperazine] (Fasudil, 10–6 M) and Y-27632 [(+)-(R)-trans-4-(1-aminoethyl)-N-(4-pyridyl) cyclohexane carboxamide dihydrochloride] (10–6 M) incubation increased the rosuvastatin-induced relaxation only in the presence of endothelium. CONCLUSIONS: The results demonstrate for the first time that in calf cardiac vein, rosuvastatin induced endothelium-dependent relaxations while Rho-kinase inhibition increased these relaxations in the presence of endothelium layer (Fig. 3, Ref. 44). |
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| Keywords: calf cardiac vein, endothelium-dependent relaxation, Rho-kinase, rosuvastatin | ||
| Published online: 24-Aug-2015 | ||
| Year: 2015, Volume: 116, Issue: 8 | Page From: 494, Page To: 498 | |
| doi:10.4149/BLL_2015_095 |
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