Home General Physiology and Biophysics 2015 General Physiology and Biophysics Vol.34, No.4, p.393–398, 2015

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Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
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General Physiology and Biophysics Vol.34, No.4, p.393–398, 2015

Title: Lymph node mapping using quantum dot-labeled polymersomes
Author: Rumiana Bakalova, Zhivko Zhelev, Biliana Nikolova, Shuhei Murayama, Desislava Lazarova, Iana Tsoneva, Ichio Aoki
Abstract: The present study was designed to investigate whether poly-ion complex hollow vesicles (polymersomes), based on chemically-modified chitosan, are appropriate for lymph node mapping in the context of their application in the development of theranostic nanosized drug delivery systems (nano-DDS). The experiments were performed on Balb/c nude mice (colon cancer-grafted). The mice were subjected to anesthesia and quantum dot (QD705)-labeled polymersomes (d~120 nm) were injected intravenously via the tail vein. The optical imaging was carried out on Maestro EX Imaging System (excitation filter: 435–480 nm; emission filter: 700 nm). A strong fluorescent signal, corresponding to QD705 fluorescence, was detected in the lymph nodes, as well as in the tumor. A very weak fluorescent signal was found in the liver area. The half-life of QD705-labelled polymersomes was 6 ± 2 hours in the bloodstream and 11 ± 3 hours in the lymph nodes. The data suggest that polymersomes are very promising carriers for lymph node mapping using QD as a contrast agent. They are useful matrix for development of nano-formulations with theranostic capabilities.
Keywords: Polymersomes — Quantum dot — Lymph nodes — Imaging
Published online: 21-Sep-2015
Year: 2015, Volume: 34, Issue: 4 Page From: 393, Page To: 398
doi:10.4149/gpb_2015007


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