General Physiology and Biophysics Vol.34, No.4, p.449

General Physiology and Biophysics Vol.34, No.4, p.449–452, 2015

Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
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General Physiology and Biophysics Vol.34, No.4, p.449–452, 2015
Title: Rosmarinic acid mitigates signs of systemic oxidative stress in streptozotocin-induced diabetes in rats
Author: Ruzena Sotnikova, Barbara Kaprinay, Jana Navarova

Abstract: The aim of the work was to study the effect of rosmarinic acid (RA) on markers of oxidative stress in rats with diabetes. Diabetes was induced by streptozotocin (STZ), RA was administered orally for ten weeks. Water consumption was measured daily. Ten weeks after the first RA administration, urine was collected over 15 hours. N-acetyl-β-D-glucosaminidase (NAGA) activity, levels of thiobarbituric acid reactive substances (TBARS) and glutathione (GSH) were determined in the pancreas, kidney, and plasma. RA administration to diabetic rats ameliorated markers of oxidative stress, as well as water consumption and urination. We assume that RA may mitigate STZ-induced diabetic manifestations by protecting rat tissues against damaging effect of free radicals.

Keywords: Rosmarinic acid — Experimental diabetes in rats — Oxidative stress
	Published online: 21-Sep-2015
Year: 2015, Volume: 34, Issue: 4	Page From: 449, Page To: 452
doi:10.4149/gpb_2015025
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