Home Bratislava Medical Journal 2015 Bratislava Medical Journal Vol.116, No.9, p.554–559, 2015

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564


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Bratislava Medical Journal Vol.116, No.9, p.554–559, 2015

Title: Petroselinum crispum extract attenuates hepatic steatosis in rats fed with fructose enriched diet
Author: V. Yuneesha Nair, N. Balakrishanan, J. Victor Antony Santiago


OBJECTIVE: This study was aimed to investigate the effects of addiction to nicotine and morphine and their withdrawal on coronary angiogenesis and serum NO concentrations in two-kidney one-clip hypertensive (2K1C) rats.

METHODS: Male hypertensive rats were divided into the two below groups: Group (1): Rats received saline for 8 weeks (n = 8); Group (2): Rats received morphine and nicotine for 8 weeks (n = 32).

At the end of 8 weeks, the groups (2) were divided into the four sub-groups, which three of them were treated with withdrawal drugs. Following treatments, blood pressure, heart rate, plasma renin activity (PRA), NO concentration and capillary density were measured.

Results showed that blood pressure was significantly reduced in the addicted group when compared to non-addicted (p < 0.05).

The withdrawal completely reversed blood pressure to the level observed pre-addiction (p < 0.05).

Coronary angiogenesis was significantly lower in the addicted group in comparistion to normal (p < 0.05) but withdrawal of addiction did not improve angiogenesis.

CONCLUSION: On the basis of the present findings, it may be indicative that the risk of cardiovascular complications in addiction is concurrent to chronic hypertension, which shows the importance of early diagnosis and treatment in clinical condition (Fig. 4, Ref. 59).

Keywords: Petroselinum crispum, non alcoholic fatty liver disease, non alcoholic steatohepatitis, lipid-hepatic function indicator.
Published online: 28-Sep-2015
Year: 2015, Volume: 116, Issue: 9 Page From: 554, Page To: 559

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