Home 
FOR AUTHORS Bratislava Medical Journal 2015 Bratislava Medical Journal Vol.116, No.9, p.560–566, 2015
FOR AUTHORS Bratislava Medical Journal 2015 Bratislava Medical Journal Vol.116, No.9, p.560–566, 2015
Journal info
|
||||
Select Journal
Journals
Bratislava Medical Journal 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 Ekologia - Ecology Endocrine Regulations General Physiology and Biophysics Neoplasma Acta Virologica Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudba 2025Webshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
Bratislava Medical Journal Vol.116, No.9, p.560–566, 2015 |
||
| Title: Effect of sinapic acid on 1,2 dimethylhydrazine induced aberrant crypt foci, biotransforming bacterial enzymes and circulatory oxidative stress status in experimental rat colon carcinogenesis | ||
| Author: C. Balaji, J. Muthukumaran, N. Nalini | ||
| Abstract: AIM: This study was aimed to investigate the effect of sinapic acid (SA) on 1,2-dimethylhydrazine (DMH) induced experimental rat colon carcinogenesis. MATERIALS AND METHODS: Rats were assorted into six groups, group 1 served as control, group 2 received SA (80 mg/kg b.w.) post orally every day until the end of the experimental period of 16 weeks, groups 3–6 rats were injected DMH (20 mg/kg b.w.) subcutaneously once a week for first four weeks. In addition, groups 4–6 rats received different doses of SA (20, 40 and 80 mg/kg b.w.). RESULTS: Our results showed that DMH induced rats revealed significantly increased ACF development and multiplicity, which were significantly inhibited on supplementation with SA. Moreover, elevated levels/activities of circulatory oxidative stress markers, faecal and colonic mucosal bacterial enzymes were observed in DMH exposed rats, which were diminished on supplementation with SA. CONCLUSION: Overall, our findings revealed that supplementation with SA offers significant protection against DMH induced rat colon carcinogenesis and the effect of SA at the dose of 40 mg/kg b.w. was more pronounced as compared to the other two doses. |
||
| Keywords: colon cancer, sinapic acid, aberrant crypt foci, bacterial enzymes | ||
| Published online: 28-Sep-2015 | ||
| Year: 2015, Volume: 116, Issue: 9 | Page From: 560, Page To: 566 | |
| doi:10.4149/BLL_2015_109 |
||
|
|
 download file |
|