Home Acta Virologica 2015 Acta Virologica Vol.59, No.3, p.221-227, 2015

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Quarterly,
Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

Published in English

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Acta Virologica Vol.59, No.3, p.221-227, 2015

Title: Curcumin inhibits bovine herpesvirus type 1 entry into MDBK cells
Author: L. ZHU, X. DING, D. ZHANG, CH. YUAN, J. WANG, E. NDEGWA, G. ZHU

Abstract: The generation of antiviral drugs from herbs and other natural resources with traditionally long-confirmed effects is an efficient approach. So far, no herb or components from herbs that could inhibit bovine herpesvirus type 1 (BoHV-1) replication have been described. In this study, the antiviral effect of curcumin, a natural phenolic constituent of the spice turmeric, on BoHV-1 replication was evaluated in cell culture. We demonstrated that curcumin impairs BoHV-1 viral particles and affects the virus post-binding entry process. Furthermore, curcumin upregulated the proportion of the plasma membrane adopting a lipid raft conformation in MDBK cells, which supported the previous reports that curcumin can modulate the lipid bilayer. Though the antiviral mechanism of curcumin on BoHV-1 needs further study, we identified for the first time a component from herb that could inhibit BoHV-1 replication, in vitro.

Keywords: BoHV-1; curcumin; lipid raft; virus entry
Year: 2015, Volume: 59, Issue: 3 Page From: 221, Page To: 227
doi:10.4149/av_2015_03_221


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