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Acta Virologica 2015 Acta Virologica Vol.59, No.3, p.265-275, 2015
Acta Virologica 2015 Acta Virologica Vol.59, No.3, p.265-275, 2015
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Acta Virologica Vol.59, No.3, p.265-275, 2015 |
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| Title: Porcine epidemic diarrhea virus M protein blocks cell cycle progression at S-phase and its subcellular localization in the porcine intestinal epithelial cells | ||
| Author: X. G. XU, H. L. ZHANG, Q. ZHANG, J. DONG, Y. HUANG, D. W. TONG | ||
| Abstract: Porcine epidemic diarrhea (PED) caused by virulent strains of porcine epidemic diarrhea virus (PEDV) is a highly contagious enteric disease of swine characterized by severe enteritis, vomiting, and watery diarrhea. This study investigates the subcellular localization and function of PEDV M protein through examination of its effects on cell growth, cell cycle progression, and interleukin 8 (IL-8) expression. Our results revealed that the PEDV M protein is localized throughout the cytoplasm. The M protein altered swine intestinal epithelial cell line (IEC) growth and induced cell cycle arrest at the S-phase via the cyclin A pathway. The S-phase arrest is associated with a decrease in level of cyclin A. Furthermore, our results revealed that the M protein of PEDV does not induce endoplasmic reticulum (ER) stress and does not activate NF-κB which is responsible for IL-8 and Bcl-2 expression. This is the first report to demonstrate that the PEDV M protein is localized in the whole cell and induces cell cycle arrest at the S-phase. This study provides novel findings in the function of M proteins of PEDV. |
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| Keywords: PEDV M protein; S-phase; cyclin A; subcellular localization; IL-8 | ||
| Year: 2015, Volume: 59, Issue: 3 | Page From: 265, Page To: 275 | |
| doi:10.4149/av_2015_03_265 |
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