Endocrine Regulations Vol.49, No.4, p.231

Endocrine Regulations Vol.49, No.4, p.231–239, 2015

Quarterly, 50 pp. per issue
Founded: 1967
ISSN 1210-0668
E-ISSN 1336-0329

Published in English

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Endocrine Regulations Vol.49, No.4, p.231–239, 2015
Title: Spaceflight osteoporosis: current state and future perspective
Author: R. Cappellesso, L. Nicole, A. Guido, D. Pizzol

Abstract: Osteoporosis is one of the established major consequences of long-duration spaceflights in astronauts seriously undermining their health after their returning on Earth. Indeed, astronauts typically lose more bone mass during one month than postmenopausal women on Earth lose in one year. To date, countermeasures mainly consist in exercise and supplementation while pharmacological treatment as those used in postmenopausal women are not routine. However, it is evident that exercise and supplementation alone are not enough to maintain bone homeostasis. In this paper we describe the current countermeasures for bone loss during long-term spaceflight, review the modern treatment which are successfully employed to prevent osteoporosis on Earth and that could be quickly used also for astronauts and finally focus on the recent cellular and molecular understanding of bone homeostasis which might provide the basis for the development of future targeted therapies.

Keywords: osteoporosis, vitamin D, spaceflights, bone metabolism
	Published online: 20-Oct-2015
Year: 2015, Volume: 49, Issue: 4	Page From: 231, Page To: 239
doi:10.4149/endo_2015_04_231
Price: 19.80 €

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