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Bratislava Medical Journal Vol.116, No.10, p.616–620, 2015 |
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Title: Toxic effect of nano-zinc oxide | ||
Author: H. R. Espanani, Z. Faghfoori, M. Izadpanah, V. Yousefi Babadi | ||
Abstract: INTRODUCTION: Nowadays, a lot of studies were carried out about side effects of nanoparticles especially nano-zinc oxide, but unfortunately, most of these studies have been conducted with high doses. In the present study 36 male Wistar rats with approximate age of two months and weighing 300 ± 30 g were selected. After standard phases of preparation, injections were done intraperitoneally in chronic groups with zinc oxide nanoparticles (20 and 40 mg/kg) every other day and for acute groups with 200 and 400 mg/kg in a single dose. After the determined time for every group (21 days for chronic groups and 7 days for acute groups), blood samples were provided from rat hearts and also liver, kidney and testicular tissue were removed for histological studies. |
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Keywords: nano-zinc oxide, acute and chronic doses, blood parameters, oxidative stress, liver tissue. | ||
Published online: 28-Oct-2015 | ||
Year: 2015, Volume: 116, Issue: 10 | Page From: 616, Page To: 620 | |
doi:10.4149/BLL_2015_119 |
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