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Bratislava Medical Journal Vol.116, No.11, p.648–653, 2015 |
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Title: Preoperative NT-proBNP values in patients with atrioventricular septal defect and its role as a predictor of early postoperative course | ||
Author: L. Bobik, L. Kovacikova, M. Zahorec, K. Danova | ||
Abstract: OBJECTIVES: Atrioventricular septal (AVSDC) defect presents by excessive pulmonary blood flow and congestive heart failure in children. This study was designed to identify and compare N-terminal pro-brain natriuretic peptide (NT-proBNP) values in complete and incomplete form at the time of surgery, and evaluation of postoperative course. The median value of NT-proBNP was 1420.0 pg/mL, with elevated levels in complete form (1656.0 vs 488.0 pg/mL, p < 0.001); age and weight with negative correlation. Other preoperative variables (genetic disorder, atrioventricular valve regurgitation, borderline ventricle) were not significant. Higher incidence of postoperative variables was present in complete form, namely mechanical ventilation (p < 0.03), dose and length of vasopressors (p < 0.002), ICU stay (p < 0.04), and complications (p < 0.05). NT-proBNP analysis as a predictor of postoperative course showed an association with longer ventilatory (> 48 hours) and inotropic forms of support, ICU stay, and presence of infection. |
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Keywords: NT-proBNP, atrioventricular septal defect, congestive heart failure, postoperative course | ||
Published online: 25-Nov-2015 | ||
Year: 2015, Volume: 116, Issue: 11 | Page From: 648, Page To: 653 | |
doi:10.4149/BLL_2015_124 |
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