Home Bratislava Medical Journal 2015 Bratislava Medical Journal Vol.116, No.11, p.689–694, 2015

Journal info


 


Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345
 

Aims and Scope
Editorial Info
Submission Guidelines

Select Journal







Webshop Cart

Your Cart is currently empty.

Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

Bratislava Medical Journal Vol.116, No.11, p.689–694, 2015

Title: Effects of tomato pulp on hepatic steatosis in the rats fed with high fat diet
Author: D. Mohajeri, A. Monadi

Abstract: BACKGROUND:Hepatic steatosis is one of the most common causes of chronic liver injury.
OBJECTIVES: This study was aimed to evaluate the protective effects of Solanumlycopersicum (tomato) pulp on high fat diet-induced hepatic steatosis in rats.
METHODS:Male Wistar rats were treated in 4 experimental groups including: healthy control group given standard diet, high fat diet group for induction of hepatic steatosis, high fat diet plus Clofibrate as positive control, and high fat diet plus tomato pulp for protection of liver steatosis. Finally, the groups were compared considering serum lipid profile, serum biomarkers of liver tissue injury and liver histopathological changes. The lipid peroxidation product and the activities of antioxidant enzymes were measured as the indicators of antioxidation in liver.
RESULTS:Rats fed with the high fat diet showed hypertriglyceridemia, hypercholesterolemia, increased activities of hepatocellular enzymes, significant decline in antioxidants, and elevated lipid peroxidation indices in liver. Tomato pulp treatment significantly reduced elevated markers of liver injury and malondialdehyde level, as well as brought back the liver antioxidants and the excessive accumulation of lipids in serum towards normal.
CONCLUSION: The results showed that tomato pulp exerted protective effects against hepatic steatosis in rats fed with high fat diet, possibly through its antioxidant actions (Tab. 5, Fig. 2, Ref. 40).

Keywords: high fat diet, Solanumlycopersicum L., hepatic steatosis, rat
Published online: 25-Nov-2015
Year: 2015, Volume: 116, Issue: 11 Page From: 689, Page To: 694
doi:10.4149/BLL_2015_135


download file



© AEPress s.r.o
Copyright notice: For any permission to reproduce, archive or otherwise use the documents in the ELiS, please contact AEP.