Home Acta Virologica 2015 Acta Virologica Vol.59, No.4, p.413-417, 2015

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Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.59, No.4, p.413-417, 2015

Title: Protective efficacy of IFN-ω AND IFN-λs against influenza viruses in induced A549 cells
Author: L. ŠKORVANOVÁ, P. ŠVANČAROVÁ, D. SVETLÍKOVÁ, T. BETÁKOVÁ

Abstract: The interferon system represents one of the components of the first line defence against influenza virus infection. Interferon omega (IFN-ω) is antigenetically different from IFN-α and IFN-β and can affect patients who are resistant to these IFNs. To improve the biological characterization of IFN-ω, we compared its activity with those of type I and type III IFNs in induced A549 cells. The antiviral effect on IFN-stimulated A549 cells was most apparent after infection with avian influenza virus. IFN-ω had statistically significant antiviral activity although less than IFN-β1a, IFN-λ1, or IFN-λ2. On the other hand, IFN-ω appeared more efficient than IFN-α2. Our results also indicate that IFN-λs were more suitable against human highly pathogenic virus. In this case, IFN-λ1 and IFN-λ2 were more potent than type I IFNs.

Keywords: influenza virus; interferon; replication; antiviral effect
Published online: 06-Dec-2015
Year: 2015, Volume: 59, Issue: 4 Page From: 413, Page To: 417
doi:10.4149/av_2015_04_413


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