Home FOR AUTHORS General Physiology and Biophysics 2016 General Physiology and Biophysics Vol.35, No.1, p.13-23, 2016

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.35, No.1, p.13-23, 2016

Title: Calcium versus strontium handling by the heart muscle
Author: Michal Hendrych, Veronika Olejnickova, Marie Novakova

Abstract: Calcium plays a crucial role in numerous processes in living systems, from both intracellular and intercellular signalling to blood clotting. Calcium can be replaced by strontium in various intracellular processes due to high level of their similarity and strontium thus may serve as a valuable tool for different experimental studies. On the other hand, strontium is also used in clinical medicine and is commonly taken to the human body with food and water. The negative cardiac side effects of strontium therapy of osteoporosis and bone metastases are well known, but still not fully explained. This fact explains enhanced interest in this element and its impact on human body. This article reviews effects of calcium and strontium on several biochemical and physiological processes, with special emphasis on cardiac muscle.

Keywords: Strontium — Calcium — Cardiomyocyte — Sarcoplasmatic reticulum — Mitochondria
Published online: 15-Dec-2015
Year: 2016, Volume: 35, Issue: 1 Page From: 13, Page To: 23
doi:10.4149/gpb_2015026


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