General Physiology and Biophysics Vol.35, No.1, p.55

General Physiology and Biophysics Vol.35, No.1, p.55–62, 2016

Quarterly, 80 pp. per issue
Founded: 1982
ISSN 1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.35, No.1, p.55–62, 2016
Title: Concept of relative variability of cardiac action potential duration and its test under various experimental conditions
Author: János Magyar, Kornél Kistamás, Krisztina Váczi, Bence Hegyi, Balázs Horváth, Tamás Bányász, Péter P. Nánási, Norbert Szentandrássy

Abstract: Beat-to-beat variability of action potential duration (short-term variability, SV) is an intrinsic property of mammalian myocardium. Since the majority of agents and interventions affecting SV may modify also action potential duration (APD), we propose here the concept of relative SV (RSV), where changes in SV are normalized to changes in APD and these data are compared to the control SV-APD relationship obtained by lengthening or shortening of action potentials by inward and outward current injections. Based on this concept the influence of the several experimental conditions like stimulation frequency, temperature, pH, redox-state and osmolarity were examined on RSV in canine ventricular myocytes using sharp microelectrodes. RSV was increased by high stimulation frequency (cycle lengths

Keywords: Short-term variability — Action potential duration — Cardiac ion currents — Canine myocytes
	Published online: 15-Dec-2015
Year: 2016, Volume: 35, Issue: 1	Page From: 55, Page To: 62
doi:10.4149/gpb_2015019
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