Home CUSTOMERS Bratislava Medical Journal 2015 Bratislava Medical Journal Vol.116, No.12, p.746-750, 2015

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Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

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Bratislava Medical Journal Vol.116, No.12, p.746-750, 2015

Title: The effects of low and high doses of sugammadex on kidney tissue in streptozotocin-induced diabetic rats
Author: G. Kip, H. C. Turgut, M. Alkan, M. E. Aydin, M. E. Erbatur, H. A. Kiraz, S. Kartal, H. Boyunaga, F. M. Comu, O. Erdem, M. Arslan, Y. Unal

Abstract: BACKGROUND: Sugammadex is primarily excreted via renal route. We investigated effects of low and high doses of sugammadex (16 mg/kg versus 96 mg/kg) on renal tissue samples of streptozotocin-induced diabetic rats.
MATERIAL AND METHODS: Twenty-four Wistar albino rats were divided into 4 groups. Group C (control – 0.9 % NaCl), Group DC (diabetes control; 55 mg/kg streptozotocin, IP, only), Group DR-16S (diabetes-rocuronium – 16 mg sugammadex, IV.) and Group DR-96S (diabetes- rocuronium – 96 mg sugammadex, IV). Renal tissue histopathological evaluation and antioxidant status (measurements of MDA levels and NO activities) were studied.
RESULTS: Significantly higher levels of all inflammation parameters (inflammation, degeneration/necrosis, tubular dilatation, tubular cell degeneration, dilatation in Bowman’s space, tubular hyaline casts, and lymphocyte infiltration) were found in the 96 mg/kg sugammadex group. Higher MDA tissue levels and lower NO activity were found in the 96 mg/kg sugammadex group.
DISCUSSION: We can conclude that high-dose (96 mg/kg) sugammadex administration resulted in significant renal tissue damage in diabetic rats. As a consequence, low doses of sugammadex have to be preferred in diabetic patients (Tab. 2, Fig. 4, Ref. 26).

Keywords: sugammadex, streptozotocin, diabetes, renal damage.
Published online: 15-Dec-2015
Year: 2015, Volume: 116, Issue: 12 Page From: 746, Page To: 750

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