Home HOME Neoplasma 2016 Neoplasma Vol.63, No.2, p.263-268, 2016

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.63, No.2, p.263-268, 2016

Title: Genetic risk factors of cisplatin induced ototoxicity in adult patients
Author: T. TALACH, J. ROTTENBERG, B. GAL, R. KOSTRICA, M. JURAJDA, I. KOCAK, R. LAKOMY, E. VOGAZIANOS

Abstract: Ototoxicity is an important adverse effect of using Cisplatin (cis-diamminedichloroplatinum) (CDDP) as a form of chemotherapy. The clinical picture of CDDP induced ototoxicity includes perceptive hearing impairment (reversible or permanent) and tinnitus. Ototoxicity manifests with considerable variability between patients. The objective of this prospective study was to investigate a possible genetic background to this variability. We assessed ototoxicity induced by therapeutic doses of CDDP in adult patients with germinative testicular tumors, or other tumors treated with an identical CDDP dosage scheme. Audiological examination before, during and after the treatment has shown deterioration in hearing; first in the high-frequencies and with increased CDDP cumulative doses, impairment in other frequencies as well. Occurrence of tinnitus was not dependent on the administered dose of CDDP, or the other risk factors examined in this study. The association of CDDP induced ototoxicity with genetic polymorphisms in candidate genes was examined. Our study has demonstrated an association of early onset of CDDP induced ototoxicity with the presence of two copies of GSTT1 gene (p=0,009) and with T allele of rs9332377 polymorphism in COMT gene (p=0,001).

Keywords: cisplatin, ototoxicity, DNA copy number variations, single nucleotide polymorphisms
Published online: 16-Jan-2016
Year: 2016, Volume: 63, Issue: 2 Page From: 263, Page To: 268
doi:10.4149/212_140820N391


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