Home Bratislava Medical Journal 2016 Bratislava Medical Journal Vol.116, No.1, p.36-40, 2016

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345
 

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Bratislava Medical Journal Vol.116, No.1, p.36-40, 2016

Title: Vitamin C ameliorates high dose Dexmedetomidine induced liver injury
Author: M. Arslan, S. C. Sezen, H. C. Turgut, M. Kocabiyik, H. Arpaci, F. M. Comu, L. Ozturk, M. Kavutcu

Abstract:

BACKGROUND: We investigated whether vitamin C has protective effects on rat liver tissue treated with different dexmedetomidine doses.
MATERIAL AND METHODS: Thirty five wistar albino rats were randomly divided into 5 groups (Control (0.9 % NaCl intraperitoneally (ip), Dexmedetomidine 5 μg.kg–1 (ip), Dexmedetomidine 5 μg.kg–1 ip plus Vitamin C (100 mg.kg–1), Dexmedetomidine 10 μg.kg–1 ip and Dexmedetomidine 10 μg.kg–1 ip plus Vitamin C (100 mg.kg–1). Histopathological liver injury, superoxide dismutase (SOD) activity and tissue Malondialdehyde levels were investigated.
RESULTS: Hepatocyte degeneration was significantly higher in D10 group than those in other study groups (p < 0.0001, p = 0.002, p < 0.0001, p = 0.005, respectively). Similarly, liver tissue sinusoidal dilatation and hepatocyte necrosis were significantly higher in D10 group than those in other groups (p < 0.0001, p < 0.0001, p = 0.002, p < 0.0001 and p < 0.0001, p = 0.046, p < 0.0001 and p = 0.002, respectively). Tissue MDA levels in D10 group were significantly higher than those in control, D5+Vit C and D10+Vit C groups (p = 0.028, p = 0.004, p = 0.031, respectively). SOD enzyme activity in D10 group was significantly lower than in control, D5+Vit C and D10+Vit C groups (p < 0.0001, p = 0.023 and p = 0.031, respectively).

CONCLUSION: High dose dexmedetomidine can induce hepatic injury and oxidative stress in rats while pre-treatment with vitamin C may be effective in protecting liver tissue against this newly recognized undesirable dexmedetomidine effect (Tab. 2, Fig. 5, Ref. 30).



Keywords: Dexmedetomidine, vitamin C, liver histopathology, MDA, SOD, rat
Published online: 21-Jan-2016
Year: 2016, Volume: 116, Issue: 1 Page From: 36, Page To: 40
doi:10.4149/BLL_2016_008


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