Home Bratislava Medical Journal 2016 Bratislava Medical Journal Vol.116, No.2, p.66-71, 2016

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

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Bratislava Medical Journal Vol.116, No.2, p.66-71, 2016

Title: Region-specific differences in colorectal cancer: Slovakia and Hungary have highest incidence in Europe
Author: V. Simko, E. Ginter

Abstract: Epidemiological data on colorectal cancer (CRC) exhibit high incidence in Central East Europe. Hungary, Slovakia and Croatia represent the lead. For decades it was the Czech Republic but it attained the fourth rank after the mid-2000. Remarkably, the Ashkenazi Jews who imigrated to the USA from Central Europe have the highest incidence of CRC among US minorities. They also have high incidence of inflammatory bowel disease, a risk for CRC. Notably, countries surrounding the Central European focus of CRC, Austria, Germany, Poland, Romania, Ukraine and Russia have substantially lower incidence. CRC in Central Europe has higher incidence than CRC among the highest at-risk cohort in the USA, the elderly blacks. Research and the genome wide screening identified genetic mutations associated with CRC in Ashkenazis from Central Europe. Some risk factors for CRC are non genotypic as evidenced by wide variation in CRC incidence in the course of only a few decades. Recent trends offer hope that identification of the non-innate pathogenic mechanisms would potentially reduce the burden of this third most lethal malignancy (Tab. 1, Fig. 4, Ref. 40).

Keywords: colorectal cancer, inflammatory bowel, Hungary, Slovakia, Croatia, Ashkenazi Jews of Central Europe, genotypic and innate risk, probiotic immunomodulation of intestinal cells
Published online: 24-Jan-2016
Year: 2016, Volume: 116, Issue: 2 Page From: 66, Page To: 71

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