Home Bratislava Medical Journal 2016 Bratislava Medical Journal Vol.116, No.2, p.94-99, 2016

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.5

 

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Bratislava Medical Journal Vol.116, No.2, p.94-99, 2016

Title: Exercise improves hippocampal estrogen and spatial memory of ovariectomized rats
Author: S. Kaidah, S. K. Soejono, G. Partadiredja
Abstract: OBJECTIVE: The present study aimed at examining the effects of regular exercise on hippocampal estrogen and estrogen receptor β (ERβ) levels, as well as the spatial memory of ovariectomized rats.
BACKGROUND: A decrease of estrogen levels leads to dysfunctions of hippocampus, including spatial learning and memory. Studies have shown that physical exercise improved spatial memory of ovariectomized rats and was associated with an increased extragonadal aromatization. This in turn affects the expression of estrogen receptors.
METHODS: Ovariectomized Sprague Dawley rats were randomly assigned into the two groups, i.e. exercise and control groups. Rats of the exercise group were trained to run on a treadmill. The exercise was performed five times per week for 12 weeks. The spatial memory of rats was measured using the Morris water maze. The hippocampal estrogen and ERβ  levels of rats were determined using ELISA.
RESULTS: The spatial memory retention of the exercise group was significantly better than that of the control group. The hippocampal estrogen level of the exercise group was significantly higher than that of the control group.
CONCLUSION: Regular exercise increases hippocampal estrogen levels and improves spatial memory retention of ovariectomized rats (Tab. 1, Fig. 4, Ref. 53).
Keywords: ovariectomy, spatial memory, estrogen receptor β
Published online: 24-Jan-2016
Year: 2016, Volume: 116, Issue: 2 Page From: 94, Page To: 99
doi:10.4149/BLL_2016_019


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