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Bratislava Medical Journal 2016 Bratislava Medical Journal Vol.116, No.2, p.106-111, 2016
Bratislava Medical Journal 2016 Bratislava Medical Journal Vol.116, No.2, p.106-111, 2016
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Bratislava Medical Journal Vol.116, No.2, p.106-111, 2016 |
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| Title: Co-administration of cisplatin and curcumin does not alter mood-associated behaviors | ||
| Author: E. A. Demir, M. Oz, M. I. Alp, H. S. Gergerlioglu, K. E. Nurullahoglu Atalik, F. H. Yerlikaya | ||
| Abstract: OBJECTIVES: Cisplatin (cis-diamminedichloroplatinum (II)) is a widely-used platinum-based chemotherapeutic agent which has dose-limiting side-effects. Also, the drug resistance is another instance that decreases treatment success in cisplatin chemotherapy. The growing body of evidence suggests that curcumin, a polyphenolic compound extracted from the spice turmeric, may exert synergistic effects and sensitize malign cells to cisplatin, while alleviating cytotoxicity-related side-effects. The present study was aimed to investigate mood-associated interactions between cisplatin and curcumin. MATERIALS AND METHODS: Thirty-four adult male Wistar albino rats were randomly assigned to four groups as control, curcumin (300 mg/kg/day, p.o. for 5 weeks), cisplatin (5 mg/kg/week, i.p. for 5 weeks), and curcumin plus cisplatin (same doses as above). The open field, elevated plus maze, and forced swim tests were engaged to evaluate mood-associated behaviors. RESULTS: We demonstrated that depression- and anxiety-like behaviors were not altered by the administration of curcumin along with the chronic cisplatin treatment. CONCLUSION: According to the results of the present study, we concluded that curcumin might be regarded as a safe adjuvant in cisplatin chemotherapy in terms of the mood-associated behaviors (Fig. 4, Ref. 41). |
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| Keywords: cisplatin, curcumin, depression, anxiety; locomotion, exploration | ||
| Published online: 24-Jan-2016 | ||
| Year: 2016, Volume: 116, Issue: 2 | Page From: 106, Page To: 111 | |
| doi:10.4149/BLL_2016_021 |
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