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Neoplasma Vol.63, No.3, p.477-483,2016 |
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| Title: Prognostic significance of GRP78/BiP expression in patients with Stage III/IV hypopharyngeal squamous cell carcinoma | ||
| Author: K. KAIRA, M. TOYODA, A. SHIMIZU, H. IMAI, K. Sakakura, O. NIKKUNI, M. SUZUKI, M. IIJIMA, T. ASAO, K. CHIKAMATSU | ||
| Abstract: The immunoglobulin heavy chain binding protein (BiP)/glucose-regulated protein 78 (GRP78) plays an essential role in the endoplasmic reticulum (ER) stress, and GRP78/BiP is known to be highly expressed in various human neoplasms. The clinicopathological features of GRP78/BiP expression in patients with advanced hypopharyngeal squamous cell carcinoma (HSCC) remain unclear. The aim of this study is to elucidate the prognostic significance of GRP78/BiP for HSCC. A total of 68 patients with advanced HSCC (stage III/IV) were analyzed, and tumor specimens were stained with immunohistochemistry for GRP78/BiP, Ki-67, and microvessel density (MVD), as determined through CD34 and p53 levels. GRP78/BiP was highly expressed in 80.8% (55/68) of all patients. The expression level of GRP78/BiP disclosed no significant relationship with any variables. Multivariate analysis confirmed that low expression of GRP78/BiP was an independent prognostic factor for predicting poor overall survival and progression-free survival in patients with advanced HSCC. The decreasing expression of GRP78/BiP was identified as a significant predictor related to shorter survival duration after surgery for advanced HSCC. Our study suggests that the reduced expression of GRP78/BiP contributes to worse survival for patients with advanced head and neck cancer. |
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| Keywords: GRP78/BiP, ER stress, hypopharynx, head and neck cancer, squamous cell carcinoma, immunohistochemistry | ||
| Published online: 16-May-2016 | ||
| Year: 2016, Volume: 63, Issue: 3 | Page From: 477, Page To: 483 | |
| doi:10.4149/319_151002N513 |
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