Home Acta Virologica 2016 Acta Virologica Vol.60, No.1, p.3-14, 2016

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Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.60, No.1, p.3-14, 2016

Title: Dengue vaccine: an update on recombinant subunit strategies
Author: J. MARTIN, L. HERMIDA

Abstract: Dengue is an increasing public health problem worldwide, with the four serotypes of the virus infecting over 390 million people annually. There is no specific treatment or antiviral drug for dengue, and prevention is largely limited to controlling the mosquito vectors or disrupting the human-vector contact. Despite the considerable progress made in recent years, an effective vaccine against the virus is not yet available. The development of a dengue vaccine has been hampered by many unique challenges, including the need to ensure the absence of vaccine-induced enhanced severity of disease. Recombinant protein subunit vaccines offer a safer alternative to other vaccine approaches. Several subunit vaccine candidates are presently under development, based on different structural and non-structural proteins of the virus. Novel adjuvants or immunopotentiating strategies are also being tested to improve their immunogenicity. This review summarizes the current status and development trends of subunit dengue vaccines.

Keywords: dengue; vaccine; subunit; recombinant protein
Published online: 16-Mar-2016
Year: 2016, Volume: 60, Issue: 1 Page From: 3, Page To: 14
doi:10.4149/av_2016_01_3


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