Home Acta Virologica 2016 Acta Virologica Vol.60, No.1, p.15-26, 2016

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Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

Published in English

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Acta Virologica Vol.60, No.1, p.15-26, 2016

Title: Lymphocytic choriomeningitis virus: ways to establish and maintain non-cytolytic persistent infection
Author: M. Labudová, J. Pastorek, S. Pastoreková

Abstract: Lymphocytic choriomeningitis virus (LCMV) is a prototype virus of the Arenaviridae family that is attracting considerable attention both as an important experimental model system to study acute and persistent viral infections, and as a neglected human pathogen of clinical significance. Notably, LCMV is capable of persisting in an infected host, and escaping the immune system. Here we describe the strategies used by the virus to establish and maintain long-term infection in vitro and/or persistent infection in vivo. We discuss how the viral components (RNA, nucleoprotein, glycoprotein, Z protein) manipulate the host cell machinery to facilitate survival and spread of the virus without disturbing the basal cellular processes. Deep understanding of these strategies is inevitable for the development of approaches towards restricting the virus spread and/or preventing its harmful reactivation. This review summarizes the current status in this area and presents ideas emerging from existing data.

Keywords: lymphocytic choriomeningitis virus; arenaviruses; persistent infection
Published online: 16-Mar-2016
Year: 2016, Volume: 60, Issue: 1 Page From: 15, Page To: 26
doi:10.4149/av_2016_01_15


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