Home Acta Virologica 2016 Acta Virologica Vol.60, No.1, p.71-77, 2016

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Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.60, No.1, p.71-77, 2016

Title: Kinetic analysis of RNA editing of Newcastle disease virus P gene in the early period of infection
Author: X. QIU, Q. FU, C. MENG, S. YU, Y. ZHAN, L. DONG, T. REN, Y. SUN, L. TAN, C. SONG, X. HAN, C. DING

Abstract: As a paramyxovirus, Newcastle disease virus (NDV) has the ability to edit its P (phosphoprotein) gene to synthesize three kinds of viral protein (P, V and W). It is technically very difficult to differentiate P, V and W mRNAs, and little was known about NDV regulation of RNA-editing frequency. To investigate the rules of NDV RNA editing, the ratio of the P gene-derived transcripts (P, V and W) was determined by sequencing at different time points post-infection. The results showed unstable ratio of V and W mRNA at different time points, and the frequency of NDV editing was significantly increased at the early period of infection (P 

Keywords: Newcastle disease virus; phosphoprotein; RNA editing; G insertion
Published online: 16-Mar-2016
Year: 2016, Volume: 60, Issue: 1 Page From: 71, Page To: 77
doi:10.4149/av_2016_01_71


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