Home Bratislava Medical Journal 2016 Bratislava Medical Journal Vol.116, No.4, p.231-234, 2016

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

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Bratislava Medical Journal Vol.116, No.4, p.231-234, 2016

Title: Apoptosis induced by boric anhydrite (B2O3) after partial hepatectomy in rat liver
Author: A. Ozen, M. Canbek

Abstract: Boron is one of the important elements that have a cell-growth suppressing effect. The apoptotic effects of B2O3 that were investigated in rats on liver regeneration following 70 % partial hepatectomy (PH). Wistar albino male rats were used and divided into 4 groups (n = 7). The Saline control groups were given only a single dose of saline; the B2O3-treated groups that were only given a single dose of 1800 mg.kg–1 B2O3 by means of intraperitoneal injections following hepatectomy. Three and 6 hours after surgical procedures, all the groups were dissected and liver tissue samples were taken from the groups for NF-κB for caspase-3 gene and protein levels investigation by RT-PCR and TaqMan Protein Assay and histological analyses by TUNEL assay.
B2O3-treated animals were examined and it was observed that NF-κB levels were decreased; however, caspase-3 gene expression and protein levels were increased significantly. This study demonstrated that B2O3 induces caspase-3 and inhibits NF-κB at the early stage of liver regeneration (Fig. 4, Ref. 26).

Keywords: liver regeneration, RT-PCR, caspase-3, NF-κB, TaqMan Protein Assay, TUNEL assay
Published online: 04-Apr-2016
Year: 2016, Volume: 116, Issue: 4 Page From: 231, Page To: 234

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