Home Bratislava Medical Journal 2016 Bratislava Medical Journal Vol.116, No.5, p.263-267, 2016

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564


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Bratislava Medical Journal Vol.116, No.5, p.263-267, 2016

Title: Telocytes (interstitial Cajal-like cells) in human Fallopian tubes
Author: L. Urban, M. Miko, M. Kajanova, S. Bozikova, H. Mrazova, I. Varga

Abstract: BACKGROUND: Telocytes represent a relatively newly discovered population of cells found within the various tissues and organs, including Fallopian tubes. It is presumed that telocytes could serve as a sensor of hormone levels or regulate activity of muscle peristaltic movement.
METHODS: Tissue sections from anatomically different parts of Fallopian tubes of 48 women (age 48.8±9.1) were stained for the expression of five different antigens: c-kit (CD117), CD34, vimentin, podoplanin (D2-40) and Dog-1.
RESULTS: Telocytes form a network associated with the smooth muscle cells. From the mentioned antibodies, only anti-c-kit (CD117) seems to be relatively selective specific to the telocytes, others react also with numerous other cells and tissue structures. Our results when using antibodies against podoplanin and Dog-1 are in dissonance with recent literature – with regards to our results, they are not suitable for detection of telocytes.
CONCLUSION: Methods of immunohistochemistry are suitable for identification of telocytes in Fallopian tubes. C-kit (CD117) antigens are useful for routine identification of telocytes in histological sections. This antigen can be combined with CD34 or vimentin in cases of double staining immunohistochemistry (Tab. 1, Fig. 6, Ref. 44).

Keywords: telocytes, interstitial Cajal-like cells, human Fallopian tubes, muscle peristaltic movement, tissue structures
Published online: 13-May-2016
Year: 2016, Volume: 116, Issue: 5 Page From: 263, Page To: 267

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