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Bratislava Medical Journal 2016 Bratislava Medical Journal Vol.117, No.5, p.295-298, 2016
Bratislava Medical Journal 2016 Bratislava Medical Journal Vol.117, No.5, p.295-298, 2016
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Bratislava Medical Journal Vol.117, No.5, p.295-298, 2016 |
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| Title: Investigation of histopathological effects after intra-arterial sugammadex injection in an experimental animal model | ||
| Author: H. A. Kiraz, H. Toman, M. Erbas, Y. Yuyucu Karabulut, T. Simsek, V. Hanci, M. Uzun | ||
| Abstract: PURPOSE: Intra-arterial injection of medications are related to mortality and morbidity. It was aimed to investigate the histopathological effects caused by two different intra-arterial doses of sugammadex, a new selective relaxant binding agent used to reverse the effects of steroidal systemic muscle relaxants used in surgeries carried out under general anesthesia. METHODS: A total of 15 rabbits were randomly divided into 3 groups. The control group was given 1 mL saline bolus into the central artery of the ear. The other two groups (Group Sgdx2 and group Sgdx16) were given 2 and 16 mg/kg sugammadex, respectively, intra-arterially. RESULTS: In control group, histopathological evaluation was in normal limits. The cross-sections belonging to Group Sgdx2 did not have any significant pathological change compared with control group (p > 0.05). Edema and single-cell necrosis were significantly higher in Group Sgdx16 when compared to control group (p < 0.05). In comparison to Group Sgdx2, single-cell necrosis was significantly higher in Group Sgdx16 (p < 0.05). CONCLUSION: Being broadly used in anesthesia, sugammadex should be administered with care because when given by intra-arterial route it may cause tissue damage and tissue loss and the patients’ arteries should be carefully checked (Tab. 2, Fig. 3, Ref. 21). |
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| Keywords: dose, experimental, intra-arterial, rabbit, sugammadex | ||
| Published online: 13-May-2016 | ||
| Year: 2016, Volume: 117, Issue: 5 | Page From: 295, Page To: 298 | |
| doi:10.4149/BLL_2016_058 |
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